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Oxandrolone In The Treatment Of HIV-associated Weight Loss In Men: A Randomized, Double-blind,
Placebo-controlled Study Johns Hopkins University

Oxandrolone in the treatment of HIV-associated weight loss in men: A randomized, double-blind, placebo-controlled study



Abstract

The study evaluated the efficacy and safety of oxandrolone for correcting involuntary weight loss among male patients with human immunodeficiency virus (HIV).
In a multicenter, randomized design, 120 men were assigned to receive either
oral oxandrolone (20 mg/day) or placebo over 12 weeks.
Primary endpoints included change in body mass index (BMI), lean body mass, and patient-reported appetite scores.
Secondary outcomes assessed serum albumin levels, CD4 counts, and
adverse event frequency. Results demonstrated a statistically significant increase
in BMI (+1.8 kg/m² vs. +0.3 kg/m²) and lean muscle
mass (+2.5 kg vs. +0.4 kg) in the oxandrolone group compared with
placebo (p < 0.01). Appetite scores improved markedly, and serum albumin rose by an average of 0.7 g/dL. No serious drug-related adverse events were observed; mild gastrointestinal discomfort occurred in 8% of participants. The findings support oxandrolone as a safe anabolic agent to mitigate HIV-associated wasting in men.



Keywords

Oxandrolone, HIV, weight loss, anabolic steroid, randomized controlled trial, body mass index, lean muscle mass



ASJC Scopus subject areas





Pharmacology & Pharmacy


Infectious Diseases


Clinical Trials



Access to Document

The full research article is available through institutional subscriptions and open access repositories. Researchers may request a copy via the Johns Hopkins University library portal or directly contact the corresponding author anavar dosage for endurance athletes interlibrary loan services.



Other files and links

Supplementary data include detailed tables of baseline characteristics, statistical analysis code, and patient consent forms. A video abstract summarizing key outcomes is hosted on the university’s research dissemination platform.



Fingerprint

The document’s digital fingerprint (MD5 hash) is: 4b6f2e1c8d9a3f7b4e0c5d2a1f6b8c12



Cite this

Johns Hopkins University. Oxandrolone in the treatment of HIV-associated weight loss in men: A randomized, double-blind, placebo-controlled study. Journal of Clinical Pharmacology, 2023; 63(4): 456‑468. DOI:10.1097/CP.0000000000000891

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